Ethereum Treasury Company Chairman Tom Lee maintained his year-end S&P 500 target of 7700 in an interview, viewing this as a conservative estimate. Despite the short-term impact of the war, it could benefit the U.S. economy in the long term, and the market may shift from crisis to opportunity. He pointed out that the market has already adjusted, and investors have completed their de-risking.

Affected by the U.S.-Israel-Iran conflict, Bitcoin fell nearly 5% this week. The S&P 500, Dow Jones, Nasdaq, and gold all declined in sync, while crude oil rose 7.3%. Over the past three months, the S&P 500 and Nasdaq ETFs saw $64 billion in outflows, reaching historic highs. Bitcoin's net realized profits once accelerated but subsequently fell below $70,000.

On March 21st, the US stock market opened lower and closed lower overall, with all three major indices ending in the red. The Dow Jones fell 0.97%, the S&P 500 declined 1.51%, and the Nasdaq dropped 2.01%. Technology stocks performed poorly, with Super Micro Computer plunging over 33%. Cryptocurrency-related stocks were also hit hard, with multiple individual stocks declining.

Gate News reports that on March 20, U.S. stock markets opened with all three major indices declining. The Dow Jones fell 0.26%, the S&P 500 index fell 0.29%, and the Nasdaq fell 0.47%. Cryptocurrency-related stocks followed the broader market decline. As of press time, MSTR fell 1.34%, BMNR fell 2.01%, CRCL fell 0.16%, and COIN fell 1.14%.

JPMorgan Report Warns on Global Risk Assets, Cuts S&P 500 2026 Target to 7200, Points Out Market Overly Optimistic on Iran Conflict De-escalation. Oil Prices Break Through $110, Suppressing Consumption and Earnings, with Expected Economic Growth Slowdown. If Oil Prices Remain Elevated, S&P 500 Faces 10%-15% Pullback Risk, and Market Volatility May Persist at High Levels.

According to Gate News, a Rune-associated address, co-founder of MakerDAO, recently opened a short position on the S&P 500 index, with positions increasing to $4.66 million. Meanwhile, the address holds $13.6 million in crude oil long positions and $6.1 million in U.S. stocks short positions, totaling over $20 million, possibly betting on economic stagflation.

Biopharmaceutical company Acurx Pharmaceuticals has approved a $10 million Bitcoin purchasing plan to hedge against R&D funding depreciation risks; Enfusion plans to invest 10% of excess cash into Bitcoin and Ethereum; Nature's Miracle launched a $5 million Bitcoin reserve plan, demonstrating that cryptocurrencies are being incorporated into reserve assets. Meanwhile, crypto custody service demand has grown by 40%.

American investment bank Raymond James raised its price target for Nvidia stock to $323, believing the company will achieve $12 billion in sales, demonstrating strong demand and growth prospects. Nvidia's revenue for this quarter is expected to grow 78%, with a forward price-to-earnings ratio lower than the S&P 500 index.

Hyperliquid partners with TradeXYZ to launch the first on-chain S&P 500 perpetual futures contract, authorized by S&P Dow Jones, supporting 24/7 trading and driving traditional financial products into the crypto market. HYPE token surges nearly 2%, up 76% year-to-date, while Hyperliquid leads trading volume in the commodities market.

Gate News reported that on March 19, at the U.S. stock market opening, the Dow Jones Industrial Average fell 0.55%, the S&P 500 Index declined 0.82%, and the Nasdaq Index dropped 1.35%. Precious metals stocks experienced significant declines, with Coeur d'Alene Mines Corporation (CDE.N) down 8%, Newmont Corporation (NEM.N) down 9%, and Pan American Silver Corp (PAAS.O) down 6%. The Nasdaq China Dragon Index fell 1.9%.