Groundbreaking Research on AME-1: How Amanita Muscaria Extract Influences Brain Immune Function

A significant scientific breakthrough has emerged from collaborative research between Psyched Wellness and Canada’s National Research Council. The study, soon to be published in Frontiers in Pharmacology—one of the world’s most-cited research platforms with over 202,000 peer reviewers—reveals compelling evidence about how Amanita muscaria extracts can modulate brain health through immune cell activation.

AME-1 and Microglia: The Brain’s Immune Defense System

At the heart of this discovery lies the interaction between Psyched Wellness’s proprietary Amanita muscaria extract, AME-1, and specialized brain cells called microglia. These resident immune cells serve as the central nervous system’s primary defense mechanism, working tirelessly to maintain brain health by clearing away plaques, damaged neurons, and infectious agents.

The research demonstrates that AME-1 activates human microglia cells, prompting them to produce pro-inflammatory cytokines and express crucial surface receptors. This priming effect enables microglia to respond more efficiently to threats within the brain, potentially supporting normal neurological function. For the first time, laboratory evidence shows that Amanita muscaria can positively influence these critical immune cells.

Trehalose: A Natural Compound with Multiple Benefits

Beyond the primary finding, metabolite screening technology uncovered another significant component within Amanita muscaria extracts—trehalose, a natural sugar utilized across food, cosmetics, and pharmaceutical industries. This compound appears to play an important role in mediating the inflammatory responses triggered by microglia, suggesting a multi-faceted mechanism of action for the mushroom extract.

Implications for Neurological Health

The research addresses areas where neuroinflammation may contribute to various health concerns, including migraines, depressive symptoms, and sleep disturbances. By demonstrating that Amanita muscaria can activate and modulate immune cell function in the brain, this study opens new avenues for understanding how functional mushroom extracts might support neurological wellness.

David Shisel, Chief Operations Officer of Psyched Wellness, emphasized the significance: “This publication validates the functional properties of our AME-1 extract under controlled laboratory conditions, advancing our understanding of how this compound influences brain maintenance and sustains optimal cognitive function.”

About the Research and Publisher

The National Research Council of Canada conducted this peer-reviewed study specifically examining Psyched Wellness’s proprietary Amanita muscaria extract formulation. Frontiers in Pharmacology stands as the industry’s third most-cited journal and sixth largest open science platform, with research articles garnering over 1.9 billion views globally—a testament to the rigor and transparency of the findings presented.

Psyched Wellness continues developing its line of Amanita muscaria-derived products, including water-based extracts, teas, and capsules aimed at supporting stress relief, relaxation, and sleep quality across North American markets.