How FDA RMAT Status For Zugo-cel Amid Wider Losses At CRISPR Therapeutics (CRSP) Has Changed Its Investment Story

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CRISPR Therapeutics reported significant losses in fiscal year 2025, with revenue of only US$3.51 million against a net loss of US$581.6 million. Despite these financial challenges, the FDA’s Regenerative Medicine Advanced Therapy (RMAT) designation for zugo-cel and progress in its gene-editing pipeline, including Casgevy commercialization, are shaping its investment narrative. The company’s investment story hinges on future clinical and commercial catalysts to justify ongoing heavy investment and unprofitability, making pipeline momentum a key factor for investors.

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