[Form 4] Spyre Therapeutics, Inc. Insider Trading Activity

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Spyre Therapeutics, Inc.'s Chief Medical Officer, Sloan Sheldon, exercised stock options and subsequently sold 7,958 shares of common stock. This transaction, executed under a pre-arranged Rule 10b5-1 trading plan adopted in June 2025, involved exercising options at $21.66 per share and selling the shares at $50.00 per share. The filing highlights an insider trade with a net sale of 7,958 shares valued at $397,900.

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